Biosignatures: Comparative effectiveness research in biomarker clinical studies

Parkinson's disease in women: a call for improved clinical studies and for comparative effectiveness research.

The incidence and prevalence of Parkinson's disease (PD) is expected to rise precipitously over the next several decades, as will the associated healthcare related costs. The epidemiology and disease manifestations of PD may differ when comparing women to men. Women are for example less likely to acquire PD, and in several studies have demonstrated a delayed onset of motor symptoms. Women, howe...

Challenges conducting comparative effectiveness research: the Clinical and Health Outcomes Initiative in Comparative Effectiveness (CHOICE) experience

Janna L Friedly, University of Washington Zoya Bauer, University of Washington Bryan A Comstock, University of Washington Emily DiMango, Columbia University Medical Center Assiamira Ferrara, Kaiser Foundation Research Institute Susan S Huang, University of California Irvine School of Medicine Elliot Israel, Harvard Medical School Jeffrey G Jarvik, University of Washington Andrew A Nierenberg, M...

Comparative Effectiveness and the Future of Clinical Research in Diabetes

Comparative effectiveness research (CER) has a number of features that distinguish it from clinical research in general (1,2). CER is, in essence, framed by asking the core question: for a doctor and a patient, what is the best treatment for that patient in terms of both benefits and harms? To answer that question, the process essentially would require effective translation of the following iss...

Clinical trial design in the era of comparative effectiveness research

Comparative efficiency research (COMER): meta-analysis of cost-effectiveness studies

BACKGROUND The aim of this study was to create a new meta-analysis method for cost-effectiveness studies using comparative efficiency research (COMER). METHODS We built a new score named total incremental net benefit (TINB), with inverse variance weighting of incremental net benefits (INB). This permits determination of whether an alternative is cost-effective, given a specific threshold (TIN...